We propose the first large-scale vegetation–recharge model for karst regions (V2Karst), which enables the analysis of the impact of changes in climate and land cover on karst groundwater recharge. We demonstrate the plausibility of V2Karst simulations against observations at FLUXNET sites and of controlling modelled processes using sensitivity analysis. We perform virtual experiments to further test the model and gain insight into its sensitivity to precipitation pattern and vegetation cover.